A Proven Approach To Managing Complex Regional Pain
F. Perry Wilson, MD: How ketamine helps treat chronic pain
Ketamine is a proven medical treatment that offers new hope for Complex Regional Pain Syndrome (CRPS) when traditional pain management approaches haven’t provided adequate relief.
Originally used as an anesthetic, ketamine works differently than standard pain medications by targeting the NMDA receptors in the central nervous system—addressing the neurological changes that drive CRPS pain and helping to “reset” the overactive pain signals characteristic of this condition.
Administered through carefully monitored IV infusions in our medical clinic, ketamine therapy helps interrupt the chronic pain cycles of CRPS, reduce central sensitization, and restore quality of life for patients struggling with this complex condition.
Ketamine addresses chronic pain through a fundamentally different pathway than traditional pain medications. While opioids and NSAIDs focus on symptom management, ketamine acts directly on NMDA receptors in the nervous system—the key players in how your body amplifies and maintains pain signals over time.
By blocking these receptors, ketamine interrupts central sensitization, where your nervous system gets “stuck” in a chronic pain state. This is especially effective for neuropathic pain, CRPS, and fibromyalgia, where the nervous system continues perpetuating pain even after the original injury has healed.
Ketamine helps your nervous system “unlearn” these maladaptive pain patterns, reducing the hyperexcitability that keeps pain signals firing inappropriately.
The breakthrough is that ketamine provides relief lasting weeks or months after treatment, rather than requiring daily medication that only masks symptoms. Many patients experience significant improvement after a series of infusions, with lasting relief that extends far beyond conventional pain management.
Your limb feels foreign to your body
Light touch or air triggers severe pain
Burning pain never stops—even at rest
Visible changes that others don't understand
You're avoiding movement to protect your limb
You've been told "there's nothing left to try"
CRPS amplifies pain signals through nervous system dysfunction. It’s real, it’s neurological—and it can be treated.
Ketamine surpasses simple pain masking—it addresses CRPS at its neurological foundation by restructuring the way your nervous system processes and sustains pain transmission.
While opioids and NSAIDs offer merely temporary symptom management, ketamine modulates NMDA receptors, calming overactive neural pain pathways while promoting the development of healthier sensory processing patterns.
This fundamental neural recalibration explains why the therapeutic benefits prove so profound and enduring.
IV ketamine infusions demonstrated 76% complete pain relief and 18% partial relief in CRPS patients, with pain-free periods lasting 3-6 months after initial treatment and up to 3 years following repeat infusions (Correll et al., 2004:).
Many patients notice meaningful relief within their first few infusions.
By quieting overactive nerve signals, ketamine breaks the cycle between pain, stress, and inflammation.
Less pain often means better focus, improved mood, and more energy for everyday life.
Better sleep and mental calm are common benefits as the nervous system resets.
Pain management shouldn't feel like a dead end. At One Mind, we offer:
Oversight by a board-certified anesthesiologist and pain specialist
2-hour infusions for complex pain syndromes
Designed for physical and emotional regulation
We coordinate with your PCP, therapist, or pain management team
“We help patients who were told there was nothing left to try. And we see them come back to life.”
About 2 hours (longer than mood infusions to support sustained pain relief)
2.5 – 3 hours total, including prep and recovery
Calm, private setting with medical supervisor
Some patients notice meaningful pain reduction within 1–3 sessions, while others experience gradual improvements over a full treatment series. Relief may include reduced pain intensity, improved mobility, or greater ability to engage in daily activities.
We provide follow-up boosters (if needed), integration coaching, and seamless communication with your existing providers to ensure continuity of care.
You may feel a sense of disconnection or stillness—but you’ll be safe, conscious, and medically monitored throughout.
Some patients experience several weeks to months of relief. Boosters are available based on need.
Real People, Real Results
Let’s begin with a private consultation that’s calm, caring, and completely focused on you. We’ll take things one step at a time, starting with a conversation designed to help you thrive. Our team will listen carefully, understand your unique needs, and determine if ketamine therapy is the right fit before moving forward. There’s no pressure or obligations—just compassionate support, expert guidance, and clear answers to all your questions. Fill out the form and we’ll reach out to provide the thoughtful care you deserve. Your story stays with us, always private and always respected.
Tell us your story. We’ll map the path forward.
We’ll listen, understand your needs, and see if ketamine therapy is the right fit. No pressure. No obligations. Just support, guidance, and clear answers.
Contact Us: 954-870-4768
